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Central nervous system involvement in patients with acquired immune deficiency syndrome (AIDS)
Author(s) -
Koppel Barbara S.,
Wormser Gary P.,
Tuchman Alan J.,
Maayan Shlomo,
Hewlett Dial,
Daras Michael
Publication year - 1985
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1985.tb03211.x
Subject(s) - medicine , progressive multifocal leukoencephalopathy , cryptococcosis , dementia , cytomegalovirus , population , meningitis , pediatrics , toxoplasmosis , opportunistic infection , immunology , pathology , viral disease , human immunodeficiency virus (hiv) , disease , virus , herpesviridae , environmental health
– Central nervous system involvement occurred in 28 of 121 patients with acquired immune deficiency syndrome (AIDS). The major risk factor in this AIDS population was intravenous drug abuse (64%). A neurologic symptom or disability was the principal reason for hospitalization in 16 cases (57%). Three patients had primary lymphoma of the brain and the remainder had opportunistic infections. Patients with focal neurological features usually had toxoplasmosis. Progressive headache and meningeal signs occurred with cryptococcosis. A progressive subacute dementia was probably due to cytomegalovirus. Other infections included atypical mycobacteria, candida, herpes zoster and possible progressive multifocal leukoencephalopathy.