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Human peripheral lymphocytes defined by anti‐myelin‐associated glycoprotein antiserum in healthy individuals and in patients with multiple sclerosis
Author(s) -
Tanaka Masami,
Sato Shuzo,
Miyatake Tadashi
Publication year - 1985
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1985.tb03200.x
Subject(s) - multiple sclerosis , immunology , immunofluorescence , medicine , pathology , biology , antibody
– We investigated both the association between MAG‐positive cells and active natural killer cells stained by anti‐Leu‐11 and the percentage of MAG‐positive cells in patients with multiple sclerosis (MS) by indirect immunofluorescence study. Eighty percent of MAG‐positive cells were stained with anti‐Leu‐11. The percentage of MAG‐positive cells of 41 healthy individuals was from 5.1 to 16.1% (8.5±2.7%). The percentage of Leu‐7‐positive cells (13.8 ± 4.9%) was always greater than that of MAG‐positive cells. In 5 of 17 samples from 14 patients with MS, the percentage of MAG‐positive cells was reduced. This finding was not related to disease activity and was not a pathognomonic feature of MS. The percentage of Leu‐7‐positive cells in patients with MS was not statistically different from that in healthy individuals; however, 4 patients showed a normal number of Leu‐7‐positive cells and a reduced number of MAG‐positive cells. These studies suggest that MAG‐positive cells are closely related to active natural killer cells and that “MAG” is a useful marker of human natural killer cells.