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Regional cerebral blood flow in hemiparkinsonian patients. Emission computerized tomography of inhaled 133 Xenon before and after levodopa
Author(s) -
Henriksen Leif,
Boas Jette
Publication year - 1985
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1985.tb03198.x
Subject(s) - cerebral blood flow , globus pallidus , thalamus , striatum , levodopa , medicine , anesthesia , population , cardiology , basal ganglia , nuclear medicine , parkinson's disease , central nervous system , dopamine , radiology , disease , environmental health
– Regional and mean cerebral blood flow (rCBF, CBF) were measured by tomography of inhaled 133 Xe in 18 hemiparkinsonian patients before and after levodopa (L‐dopa). Baseline mean CBF was 55 ml/ (100 g × min) after an L‐dopa‐free interval of at least 10 h (range 10–13) and remained unchanged at 56.1 ml/ (100 g × min) after optimal clinical improvement was achieved by L‐dopa. However, L‐dopa reduced rCBF significantly ( P < 0.05) in the striatum contralateral to the symptomatic limbs. In patients with adverse reactions such as hyperkinesias and on/off symptoms, flow tended to increase bilaterally in striatum and often markedly in midline structures anatomically related to globus pallidus and thalamus. Compared with a normal population, the subcortical rCBF distribution was asymmetrical with a reduced flow (−18%) in the striatum contralateral to the symptomatic limbs and in midline structures anatomically related to globus pallidus and thalamus (‐12%). Cortical CBF was inverse related to the duration of Parkinson's disease ( P < 0.05), probably reflecting an increasing mental deterioration with time.