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The brain octopamine and phenylethanolamine content in rats in thioacetamide‐induced hepatogenic encephalopathy
Author(s) -
Hilgier Wojciech,
Zitting Antti,
Albrecht Jan
Publication year - 1985
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1985.tb03188.x
Subject(s) - thioacetamide , encephalopathy , medicine , endocrinology , hepatic encephalopathy , neurotransmitter , dopamine , chemistry , pathophysiology , central nervous system , cirrhosis
– The brain octopamine (OA) and phenylethanolamine (PhEA) content was determined in rats subjected to repeated intraperitoneal administrations of thioace‐tamide (TAA) known to produce different stages of hepatogenic encephalopathy (HE). A more than 2.5‐fold increase of OA and a 2‐fold increase of PhEA was observed after prolonged (3 times) administration of TAA, coinciding with impaired ammonia detoxi‐cation in brain and with the onset of pathophysiological changes typical for HE. Only insignificant changes in the content of the amines were observed in the early stages of the experiment as well as in the recovery period. The results are consistent with the “false neurotransmitter” hypothesis of Fischer and Baldessarini, assuming the participation of OA and PhEA in the pathogenesis of HE.