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5‐hydroxytryptamine in platelets of torsion dystonia patients
Author(s) -
Korczyn Amos D.,
Lazarovits Jeanette,
Dvilanski Alexander,
Eshel Yechiel,
Nathan Ilana
Publication year - 1985
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1985.tb03184.x
Subject(s) - platelet , serotonin , dystonia , imipramine , medicine , endocrinology , chemistry , 5 ht receptor , receptor , psychology , neuroscience , pathology , alternative medicine
– In an effort to explore possible changes in 5‐hydroxytryptamine (5‐HT) metabolism in idiopathic torsion dystonia (ITD), platelets from patients were studied. Platelet 5‐HT concentrations did not differ from those in matched controls. 5‐HT uptake by the platelets was also studied, and the results demonstrated significantly higher K m values, but V max values were normal among patients. Inhibition by imipramine of 5‐HT uptake by platelets taken from ITD patients was also normal. The therapeutic implications of the low affinity of 5‐HT to its platelet receptors are discussed.