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Skeletal muscle in paramyotonia congenita: biochemistry, histochemistry and morphology
Author(s) -
Friis Mogens Laue,
Johnsen Torsten,
Saltin Bengt,
Paulson Olaf B.
Publication year - 1985
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1985.tb03168.x
Subject(s) - skeletal muscle , muscle biopsy , biceps , lactate dehydrogenase , myopathy , hexokinase , myocyte , medicine , glycogen , endocrinology , chemistry , biology , biopsy , pathology , anatomy , enzyme , biochemistry , glycolysis
– In 12 patients with paramyotonia congenita, percutaneous needle biopsies from the brachial biceps muscle were performed. Muscle fibre area, distribution of muscle fibre types I, II‐A and II‐B and capillarization were not different from healthy controls. Signs of myopathy with central nuclei in the muscle cells were noted in 9 of the patients. 4 of these patients also had small areas with degeneration and, in one, vacuoles were observed. Quantitative determination of muscle glycogen, water and protein content were within normal range as were enzyme activities for hexokinase, lactate dehydrogenase, citrate synthetase and 3‐hydroxy‐acyl‐CoA dehydrogenase.