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High levels of C 3 c in the cerebrospinal fluid from amyotrophic lateral sclerosis patients
Author(s) -
Annunziata P.,
Volpi N.
Publication year - 1985
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1985.tb01548.x
Subject(s) - cerebrospinal fluid , amyotrophic lateral sclerosis , albumin , medicine , multiple sclerosis , receptor , serum albumin , endocrinology , pathology , immunology , disease
– A study of several parameters of the humoral immunity in the serum and the cerebrospinal fluid (CSF) of thirtheen Amyotrophic Lateral Sclerosis (ALS) patients was carried out. A significant increase in CSF C 3 c was shown. This feature was found to be significantly correlated to the CSF albumin/serum albumin ratio (r = 0.70; p < 0.05) and to the total CSF proteins (r = 0.86; p < 0.01). The possible effect of the blood‐brain barrier breakdown on the CSF complement levels was evaluated. On the basis of the recently found biochemical changes in ALS cell membranes it is proposed that the high levels of the CSF C 3 c may also be due to a defective binding to the lymphocytes C 3 receptors.