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Abnormal erythrocyte survival in patients with myotonic dystrophy
Author(s) -
Sydow Olof,
Stibler Helena,
Hast Robert
Publication year - 1985
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1985.tb00911.x
Subject(s) - myotonic dystrophy , erythrocyte membrane , myotonia , medicine , sialic acid , dystrophy , endocrinology , survival rate , biology , biochemistry , gastroenterology , chemistry , pathology , membrane
– In four of six patients with myotonic dystrophy whom we studied 51 Cr labeled erythrocytes were found to have a biphasic survival kinetic. After an initial significantly more rapid disappearance than in controls, about 80% of the labeled cells reappeared in circulation, and were thereafter eliminated at a significantly faster rate than normal. This type of biphasic survival pattern may partly be related to reduced sialic acid concentration of the erythrocyte membrane in patients with this disease.