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Carbidopa dosage modifies L‐DOPA induced side effects and blood levels of L‐DOPA and other amino acids in advanced parkinsonism
Author(s) -
Pareja F. Bermejo,
MartinezMartin P.,
Muradas V.,
Yébenes J. G.
Publication year - 1985
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1985.tb00908.x
Subject(s) - carbidopa , parkinsonism , medicine , levodopa , parkinson's disease , pharmacology , disease
– Thirty‐four patients with advanced Parkinson's disease showing intolerance to therapeutic doses of L‐DOPA were treated with L‐DOPA plus carbidopa at two different proportions. Ten patients preferred medication containing 10% carbidopa while 24 preferred 25% carbidopa. The increase of carbidopa reduced gastrointestinal disturbances and psychiatric side effects related to L‐DOPA, but improvement of disability when measured according to objective tests was modest. Higher doses of carbidopa reduced peripheral DOPA metabolism and increased blood levels of tryptophan, 3‐OM‐DOPA and DOPA in relation to the administered dose.