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Correlation of the chemiluminescence‐activity of peripheral blood monocytes with CSF parameters of inflammation and the clinical course of patients with lymphocytic meningoencephalitis
Author(s) -
Hammann K. P.,
Corradini C.,
Dillmann U.,
Fischer A.,
Kleider A.,
Hopf H. Ch.
Publication year - 1985
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1985.tb00864.x
Subject(s) - chemiluminescence , meningoencephalitis , cerebrospinal fluid , monocyte , peripheral blood , inflammation , medicine , csf albumin , peripheral , immunology , gastroenterology , endocrinology , chemistry , chromatography
– The chemiluminescence‐activity (CL‐A) of peripheral blood monocytes (MO) was measured in eight patients with lymphocytic meningitis or meningoencephalitis and compared to CSF parameters and the clinical course. The initial maximum CL‐A was around four times above the control and decreased to normal values within approximately 20 days. Poor correlations were found when the CL‐A was compared to CSF parameters in the total group of patients. With regard to the CSF parameters in individual patients the CL‐A was closely related to the cell count, to a lesser degree to the protein content, but not to the IgG content. Finally, a very good correlation of the CL‐A was found with the clinical course in individual patients. This preliminary data suggests the clinical usefulness of CL‐measurements and supports the conception that the CL‐A predominantly reflects the specific cellular phase of inflammation, which is dominated by T cells.