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The effect of metrizamide on regional brain glucose metabolism in the rat
Author(s) -
Bech Lars,
Diemer Nils Henrik,
Gjedde Albert
Publication year - 1984
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1984.tb07808.x
Subject(s) - metrizamide , cisterna magna , deoxyglucose , in vivo , carbohydrate metabolism , phosphorylation , endocrinology , metabolism , medicine , in vitro , chemistry , biology , biochemistry , neuroscience , cerebrospinal fluid , myelography , microbiology and biotechnology , spinal cord
— The X‐ray contrast material metrizamide is structurally related to 2‐deoxyglucose and inhibits brain glucose phosphorylation in vitro. In vivo , the present autoradiographic study with labeled 2‐deoxyglucose revealed a global reduction of brain glucose phosphorylation after metrizamide administration in the cisterna magna of rats. The reduction averaged 18% of all regions.