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Hyperammonemia in asterixis induced by carbamazepine: two case reports
Author(s) -
Ambrosetto Giovanni,
Riva Roberto,
Baruzzi Agostino
Publication year - 1984
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1984.tb07799.x
Subject(s) - hyperammonemia , carbamazepine , abnormality , medicine , anticonvulsant , anesthesia , gastroenterology , psychiatry , epilepsy
ABSTRACT— Two patients developed asterixis while they were taking carbamazepine at “therapeutic” levels. The only laboratory abnormality was slight hyperammonemia. It occurred with normal hepatic function as a dose‐related effect. In fact, the blood ammonia level decreased and asterixis ceased when carbamazepine was stopped or reduced in dosage. The relationship between asterixis and hyperammonemia during carbamazepine therapy is discussed.