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Lymphocyte subpopulations in the blood and cerebrospinal fluid of multiple sclerosis patients in active disease
Author(s) -
Rukavina Daniel,
Sepčić Juraj,
Dorić Miljenko,
Ledić Petar,
Zaputović Luka,
Eberhardt Predrag
Publication year - 1984
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1984.tb07798.x
Subject(s) - multiple sclerosis , cerebrospinal fluid , medicine , peripheral blood , lymphocyte , disease , immunology , t lymphocyte , peripheral , peripheral blood lymphocyte , pathology , immune system
— Lymphocyte subpopulations (total T cells, active T cells and B cells) were simultaneously analyzed in peripheral blood and CSF of MS patients. All patients were in active disease, 3 to 4 weeks after first signs of disease activation appeared. Per cent levels and absolute numbers of examined lymphocyte subpopulations in the blood of MS patients were significantly lower than in healthy controls. In MS, the level of active T lymphocytes was lower in CSF than in peripheral blood. The results support our earlier observations relating to the role of active T lymphocytes in the clinical course of disease.