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In vitro toxicity of MS sera correlates with new clinical signs
Author(s) -
Bradbury K.,
Aparicio S. R.,
Sumner D. W.,
MacFie A.,
Bird C. C.
Publication year - 1984
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1984.tb00852.x
Subject(s) - toxicity , in vitro , cytotoxicity , pharmacology , medicine , chemistry , biochemistry
–In vitro toxicity of sera from 10 MS patients was followed for up to 3 years. Myelinotoxicity and cytotoxicity measured as radiolabel release from rat cerebellar explants were almost continously higher in than in controls while peaks of radiolabel release were associated with the emergence of new clinical signs in the MS patients.