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Enhanced RNA and protein synthesis in vitro in astrocytes derived from rats in the early stage of experimental hepatogenic encephalopathy
Author(s) -
Albrecht Jan
Publication year - 1984
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1984.tb00829.x
Subject(s) - thioacetamide , rna , stimulation , in vitro , stage (stratigraphy) , encephalopathy , hepatic encephalopathy , protein biosynthesis , astrocyte , neuroscience , biology , microbiology and biotechnology , pathology , chemistry , medicine , biochemistry , central nervous system , paleontology , cirrhosis , gene
– Astroglia‐enriched cell fractions derived from rats with the early symptoms of hepatogenic enecephalopathy (HE) following treatment with thioacetamide, showed an increase above control ability to incorporate radioactive precursors into RNA and proteins. These results lend support to the idea that overall stimulation of macromolecular syntheses is an important aspect of astroglial reaction preceding the appearance in astrocytes of progressive morphological changes characterizing more advanced stages of HE.