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Serum concentration of clonazepam after rectal administration
Author(s) -
Jensen Peder Klosterskov,
Abild Kirsten,
Poulsen Mette Nøhr
Publication year - 1983
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1983.tb04852.x
Subject(s) - clonazepam , rectal administration , medicine , anesthesia , absorption (acoustics) , serum concentration , status epilepticus , epilepsy , physics , psychiatry , acoustics
The purpose of the present study was to evaluate the absorption of clonazepam administered rectally. 10 adult non‐epileptics were given 0.02 mg clonazepam/kg body weight, and blood samples were drawn 0, 2, 5, 7, 10, 15, 30 and 60 min after administration. The concentrations were measured by gas‐chromatography. To gain an impression of the serum concentration after intravenous administration, 2 persons were given 1 mg clonazepam and blood samples were drawn and analyzed in the same way as after rectal administration. Peak values occurred 10 to 30 min after rectal administration; the values were between 18 and 57 nmol/l. After intravenous administration, the values were very high within the first 10‐15 min; hereafter the concentrations were about the same level as the peak values after rectal administration, indicating that clonazepam is well‐absorbed after rectal administration and can be used in the treatment of status epilepticus, possibly in larger doses than those used in this study.