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A study of urinary excretion of biogenic amine metabolites in epilepsy
Author(s) -
Baliga L.,
Rao A.,
Raja A.,
Rao S. N.
Publication year - 1983
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1983.tb04851.x
Subject(s) - metabolite , epilepsy , urinary system , excretion , endocrinology , medicine , mandelic acid , serotonin , catecholaminergic , chemistry , dopamine , psychiatry , organic chemistry , receptor
Urinary total catecholamines, their metabolites, and a metabolite of serotonin have been investigated in 20 patients with epilepsy, and in 10 controls. The levels of total catecholamines, vanillyl mandelic acid and 5‐hydroxyindole acetic acid in epileptics were not significantly different from the controls. However, the mean 3‐methoxy‐4‐hydroxyphenylglycol, excretion in cases of epilepsy was significantly increased as compared to the control group. It is concluded that a central catecholaminergic disturbance is involved in the pathogenesis of epilepsy.