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Evaluation of anticoagulants in patients with cerebral infarction with slight to moderate neurological deficit
Author(s) -
Eriksson SvenErik,
Link Hans
Publication year - 1983
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1983.tb04823.x
Subject(s) - medicine , cerebral infarction , stroke (engine) , neurological deficit , infarction , randomized controlled trial , anticoagulant , anticoagulant therapy , anesthesia , brain infarction , surgery , ischemia , myocardial infarction , mechanical engineering , engineering
In a non‐randomized controlled study carried out on 238 hospitalized patients with cerebral infarction, anticoagulant treatment (AC) was compared with the natural course in the prevention of transient ischemic attacks (TIA), cerebral infarction, stroke, stroke or death. 137 patients were allocated to AC, mean follow‐up 30.5 months, and 101 patients were allocated to the controls (untreated group), mean follow‐up 25.2 months. There were no statistically significant differences among the patients in the group who had suffered TIA (AC treated group 10.2%, untreated group 5.9%), cerebral infarction (AC treated group 10.2%, untreated group 11.9%), stroke (AC treated group 14.6%, untreated group 12.9%), stroke or death (AC treated group 22.6%, untreated group 19.8%). Minor bleedings occurred significantly more frequently ( P <0.01) in the treated group. Severe bleedings occurred in 8 patients in the treated group (5.8%) compared to 1 of the controls (1%). It is concluded from the trial that AC can only seldom be recommended as prophylactic against new strokes in patients with cerebral infarction due to arterial thromboembolism.