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Clofibrate‐induced myotonia in rats
Author(s) -
NiebrøjDobosz Irena,
Kwieciński Hubert
Publication year - 1983
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1983.tb04567.x
Subject(s) - medicine , endocrinology , chemistry , myotonia , phospholipid , clofibrate , endoplasmic reticulum , myofibril , myosin , atpase , calcium , sarcolemma , sarcoplasm , enzyme , biochemistry , membrane , biology , myotonic dystrophy
‐ Determination of enzymatic activity, protein profile and phospholipid composition of muscle plasma membranes and sarcoplasmic reticulum in rats were carried out after clofibrate injections in a dose of 0.4 g/kg body weight. In the plasma membranes, the activity of Na + + K + , Mg 2+ ATPase was insignificantly decreased, and that of 5′‐nucleotidase significantly diminished. A non‐significant change was observed in the total amount of phopholipids. The amount of phosphoethanolamine appeared to be lower. Changes in the protein profile were seen. In the sarcoplasmic reticulum, the major abberation was the decrease of Mg 2+ ATPase activity. No evident changes were observed in the phospholipid behaviour. Abnormalities in the protein profile appeared. In the myofibrillar proteins, increases of α‐actinin and troponin at the expense of myosin were observed. In the clofibrate model of myotonia in rats, the changes in the biochemical parameters were less pronounced as compared to the previously tested 20,25‐diazacholesterol model.