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Isoniazid effects on choreiform movement and on GABA, HVA and 5‐HIAA in CSF
Author(s) -
Yamamoto Mitsutoshi,
Otsuki Saburo,
Kuroda Hiroo,
Ogawa Norio
Publication year - 1983
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1983.tb04554.x
Subject(s) - choreiform movement , homovanillic acid , isoniazid , medicine , endocrinology , serotonin , pharmacology , psychology , tuberculosis , dyskinesia , receptor , disease , pathology , parkinson's disease
‐ Isoniazid was administered in 4‐week open trial in patients with choreiform movement. Gamma‐aminobutyric acid (GABA), homovanillic acid (HVA) and 5‐hydroxyindoleacetic acid (5‐HIAA) in CSF were measured before and after treatment. Isoniazid did not improve choreiform movement. CSF GABA levels were significantly increased after treatment, but HVA and 5‐HIAA levels were not significantly altered. The findings suggest that isoniazid influenced brain GABA metabolism but did not influence dopamine and serotonin metabolism in patients with chorieform movement.