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Tiapride in levodopa‐induced involuntary movements
Author(s) -
Nielsen B. Mejer
Publication year - 1983
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1983.tb03155.x
Subject(s) - hyperkinesia , tiapride , hyperkinesis , placebo , levodopa , rating scale , psychology , chorea , movement disorders , medicine , anesthesia , psychiatry , disease , parkinson's disease , developmental psychology , pathology , alternative medicine
– The effect of Tiapride on levodopa‐induced hyperkinesia and on‐off phenomena was evaluated in 13 patients with Parkinsons disease in a randomized dose‐finding, double‐blind placebo cross‐over study. The patients were checked using a modified Webster rating scale; hyperkinesia were rated on a 0–3 points scale for 5 regions and on‐off periods measured by duration and frequency. Tiapride in doses not accompanied by significant recurrence of Parkinsonian symptoms revealed no significant diminution of the involuntary movements, and no effect on on‐off periods was found.