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Dose regimen of deprenyl (selegiline) and platelet MAO activities
Author(s) -
ORELAND LARS,
JOHANSSON FOLKE,
EKSTEDT JAN
Publication year - 1983
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1983.tb01519.x
Subject(s) - selegiline , platelet , regimen , medicine , pharmacology , population , parkinson's disease , environmental health , disease
— The effect of various doses of deprenyl on thrombocyte MAO activity in parkinsonian patients has been studied. It is suggested that individual differences in the degree of inhibition are due to differences in the metabolic rate of deprenyl. The recovery of thrombocyte MAO activity was linear at a rate of approximately 10 % per day. The linearity of the recovery suggests that the disappearance of the population of thrombocytes is selected with respect to age.