Premium
The effect of deprenyl (selegiline) on intra‐and extraneuronal dopamine oxidation
Author(s) -
ORELAND LARS,
ARAI YUICHIRO,
STENSTRÖ ANDERS
Publication year - 1983
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1983.tb01518.x
Subject(s) - selegiline , striatum , dopamine , monoamine oxidase b , chemistry , caudate nucleus , endocrinology , medicine , human brain , monoamine oxidase , pharmacology , enzyme , parkinson's disease , biochemistry , psychology , neuroscience , disease
— It was found that in that rat striatum DA was oxidized extrasynaptosomally to 11 % by MAO‐A and to 3 % by MAO‐B. The corresponding intrasynaptosomal oxidations were 84 % and 2 %, respectively. Those figures were virtually unchanged even if the rat brain MAO‐B was selectively inhibited to 87 % by deprenyl. In the human brain extrasynaptosomal oxidation was 16 % and 66 %, respectively, by MAO‐A and ‐B. Intrasynaptosomally the corresponding figures were 12 % and 6 %, respectively. Selective inhibition of human caudate MAO‐B was calculated to give a total reduction of DA oxidation of 63 %. The differences between man and rat are due to the proportionately greater oxidation of DA by MAO‐B in man, which is a consequence of a higher ratio of concentration of MAO‐A/‐B in the rat.