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Increased blood‐brain barrier dysfunction around cerebral stab wounds in rats immunized to brain antigens
Author(s) -
Gannushkina Irina V.,
Johansson Barbro B.,
Persson Lennart I.
Publication year - 1982
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1982.tb06870.x
Subject(s) - extravasation , blood–brain barrier , medicine , antigen , stab wound , albumin , immunology , serum albumin , antibody , central nervous system , pathology , surgery
The extravasation of serum albumin and immunoglobulin G (IgG) was assayed by electroimmunoassay in cerebral cortex homogenates of rats subjected to stab wound injury either 2 weeks after immunisation to brain antigens or without prior immunisation. The amount of IgG in the brain was significantly higher in immunised than in non‐immunised rats 3 and 24 h after injury. A significantly enhanced extravasation of albumin in immunised rats was found only after 24 h. It is concluded that immunisation to brain antigens enhances the vulnerability of the blood‐brain barrier in rats subjected to stab wound injury.