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The blood‐brain barrier is impermeable to metrizamide
Author(s) -
Gjedde Albert
Publication year - 1982
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1982.tb06861.x
Subject(s) - metrizamide , blood–brain barrier , intracellular , chemistry , endothelium , medicine , biophysics , endocrinology , central nervous system , neuroscience , biochemistry , biology , myelography , spinal cord
The X‐ray contrast material metrizamide is a glucose analog, related to 2‐deoxy‐D‐glucose. The cerebral capillary endothelium, or blood‐brain barrier, is completely impermeable to this compound. It is unlikely, therefore, that metrizamide pass any cell membranes. Since the affinity for rat brain hexokinase is three orders of magnitude below that of Dglucose, it is equally unlikely that metrizamide attain intracellular concentrations in brain sufficient to inhibit glucose phosphorylation.