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Sequential determinations of cerebrospinal fluid lactate dehydrogenase isoenzyme in human brain tumors on treatment
Author(s) -
Vivekanandan S.,
Rao A. P. Kamalakara,
Selvam R.,
Kanaka T. S.
Publication year - 1982
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1982.tb06855.x
Subject(s) - cerebrospinal fluid , lactate dehydrogenase , isozyme , medicine , pathology , l lactate dehydrogenase , enzyme , biology , biochemistry
51 sequential determinations of cerebrospinal fluid (CSF) lactate dehydrogenase (LDH) isoenzyme in 5.5% polyacrylamide gel were performed in 26 samples from patients with brain tumors. The assay was made prior to and after treatment. 26 untreated patients demonstrated elevated total LDH activity. 17 of 26 patients showed altered isoenzyme pattern. Disappearance of LDH 5 , decrease of LDH 4 and relative increase of LDH 2 were accompanied by improvement in clinical status in 15 of 26 patients. This suggests the utility of the CSF LDH isoenzyme pattern to monitor the clinical status of treatment in brain tumors.