Premium
Significance of serum myoglobin in neuromuscular diseases and in carrier detection of Duchenne muscular dystrophy
Author(s) -
NørregaardHansen K.,
HeinSørensen O.
Publication year - 1982
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1982.tb04523.x
Subject(s) - myoglobin , creatine kinase , duchenne muscular dystrophy , muscular dystrophy , medicine , endocrinology , chemistry , biochemistry
In a retrospective study, the serum myoglobin concentration (S‐myoglobin) was determined in patients with neuromuscular diseases and in carriers of Duchenne muscular dystrophy (DMD). Myoglobin was quantified by a sensitive radioimmunoassay. Serum creatine kinase (CK, EC 2.7.3.2) activity (S‐CK) and serum creatine kinase B‐subunit activity (S‐CKB) were determined for comparison. Sera from 70 patients with various neuromuscular diseases and from 17 female relatives of patients with DMD were analysed. Increased levels of S‐myoglobin were found both in dystrophic and in spinal myopathies. Because of a marked overlap of the range of values between the different dystrophic myopathies and even between the dystrophic and the spinal myopathies, S‐myoglobin is of little value in the final diagnosis of neuromuscular diseases. In the detection of carriers of DMD, simultaneous determination of S‐myoglobin and S‐CK gave a higher detection rate compared to the detection rate with S‐CK. S‐CKB was normal in all carriers and only elevated in some of the patients with DMD and limb girdle muscular dystorphy.