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“On‐off” phenomena, dyskinesias and dystonias
Author(s) -
Frattola Lodovico,
Albizzati Maria Grazia,
Bassi Sirio,
Ferrarese Carlo,
Trabucchi Marco
Publication year - 1982
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1982.tb04520.x
Subject(s) - lisuride , apomorphine , dyskinesia , spasmodic torticollis , medicine , anesthesia , parkinson's disease , psychology , tardive dyskinesia , physical medicine and rehabilitation , psychiatry , dopaminergic , dystonia , dopamine agonist , schizophrenia (object oriented programming) , dopamine , disease
In this study the effects of an acute injection of lisuride and apomorphine in 12 subjects affected by dystonic‐dyskinetic syndromes of different aetiology are evaluated: 3 patients with spasmodic torticollis, 4 with tardive dyskinesia and 5 Parkinson patients suffering from “on‐off” attacks with prominent dyskinesias during the mobile phase. In the last group drugs were administered during the “on” phase. In 11 out of 12 patients both lisuride and apomorphine induced a marked improvement of the abnormal involuntary movements. In Parkinson and torticollis patients both drugs also reduced the rigidity. In comparison to apomorphine, lisuride showed a more effective and long‐lasting action. Only in one Parkinson patient did the drugs fail in showing any change.