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Prophylactic treatment of migraine with tolfenamic acid
Author(s) -
Mikkelsen Bjarne Majlund,
Falk Jørgen Viggo
Publication year - 1982
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1982.tb03134.x
Subject(s) - migraine , placebo , vomiting , medicine , anesthesia , crossover study , prophylactic treatment , nausea , gastroenterology , alternative medicine , pathology
In 31 patients with more than 2 migraine attacks per month the prophylactic effect of tolfenamic acid and placebo was compared in a double‐blind crossover study. The patients were treated for 10 weeks with each preparation, with a 2‐week break in treatment between the preparations. Tolfenamic acid had a significantly better effect in relation to the preferences of the patients, the number of attacks, the total duration of the attacks, the degree of severity, the number of episodes of vomiting, and work capacity. Mild symptoms and complaints occurred in both treatment periods, but they were qualitatively and quantitatively similar. Laboratory investigations of blood, liver function, and kidney function showed no changes whilst on treatment with either preparation. It is therefore concluded that tolfenamic acid can be used in the prophylactic treatment of migraine.