Premium
Brain monoamine abnormalities in the two types of Creutzfeldt‐Jakob disease
Author(s) -
Nyberg P.,
Almay B. G. L.,
Carlsson A.,
Masters C.,
Winblad B.
Publication year - 1982
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1982.tb03125.x
Subject(s) - monoamine neurotransmitter , dopamine , catecholaminergic , disease , encephalopathy , medicine , neuroscience , pathology , biology , serotonin , receptor
Analysis of monoamine concentrations in brain tissue was carried out on the two types of Creutzfeldt‐Jakob disease (CJD). The results showed decreased levels of catecholamines compared to control cases in a number of areas, and the reductions were most pronounced for dopamine. In general, the case classified as the amyotrophic form of CJD showed a greater degree of a monoamine loss than the case with spongiform encephalopathy, which is the typical transmissible form of CJD. These findings support the scarce available data indicating disturbances in the catecholaminergic systems in these types of brain diseases, and may have therapeutic implications.