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Cerebrovascular permeability and cerebral blood flow in hypertension induced by gammahydroxybutyric acid
Author(s) -
Johansson Barbro,
Hardebo JanErik
Publication year - 1982
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1982.tb03102.x
Subject(s) - extravasation , evans blue , jugular vein , albumin , medicine , anesthesia , aorta , blood–brain barrier , blood pressure , cerebral blood flow , blood flow , vascular permeability , intraperitoneal injection , endocrinology , central nervous system , pathology
A sustained increase in blood pressure was obtained by intraperitoneal (i.p.) or intravenous (i.v.) administration of gammahydroxybutyric acid (GHBA, 1 g/kg) in rats under nitrous oxide anesthesia and in conscious rats with indwelling catheters in the aorta and a jugular vein. Evans blue‐albumin and 125 I‐labeled serum albumin, given i.v. before GHBA, were used to study the function of the blood‐barrier in rats killed 60 min after the injection of the drug. Brains from rats subjected to acute hypertension while awake showed less extravasation of albumin than did brains from anesthetized rats. Sectioning of the cervical symphatetic nerves did not increase extravasation in conscious rats. The cerebral blood flow, determined with the 14 C‐ethanol technique, did not significantly differ in GHBA‐treated rats and controls. Because of the sustained increase in blood pressure, GHBA‐induced hypertension might be a useful model for the study of long‐term effects on the brain of hypertensive opening of the blood‐brain barrier.