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Long‐time penicillamine‐treatment in Amyotrophic Lateral Sclerosis with parallel determination of lead in blood, plasma and urine
Author(s) -
Conradi S.,
Ronnevi L.O.,
Nise G.,
Vesterberg O.
Publication year - 1982
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1982.tb03078.x
Subject(s) - penicillamine , amyotrophic lateral sclerosis , medicine , lead (geology) , urine , urinary system , surgery , biology , disease , paleontology
Six ALS‐patients were given long‐term penicillamine treatment. A rapid, long‐lasting increase in urinary lead was provoked, whereas whole blood and plasma lead were unchanged. In four patients, the progress did not change markedly, one patient deteriorated rapidly and in one patient the progression slowed down after one and a half years of treatment.