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Advanced catecholaminergic disturbances in the brain in a case of Wilson's disease
Author(s) -
Nyberg P.,
Gottfries C.G.,
Holmgren G.,
Persson S.,
Roos B.E.,
Winblad B.
Publication year - 1982
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1982.tb03063.x
Subject(s) - dopamine , basal ganglia , catecholaminergic , hypothalamus , monoamine neurotransmitter , medicine , endocrinology , disease , basal (medicine) , psychology , neuroscience , central nervous system , serotonin , receptor , insulin
The patient presented is an eight‐year‐old girl who died of Wilson's disease. Monoamines were analyzed in the brain and the results were compared with those obtained from 19–48 patients who had died of non‐neurological somatic diseases. The brain from the Wilson patient had greatly increased noradrenaline concentrations and greatly decreased dopamine concentrations of the basal ganglia, whereas the opposite was seen in the hypothalamus.