Premium
Acetylcholinesterase activities in cerebrospinal fluid of patients with senile dementia of Alzheimer type
Author(s) -
Soininen H.,
Halonen T.,
Riekkinen P. J.
Publication year - 1981
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1981.tb04401.x
Subject(s) - acetylcholinesterase , cerebrospinal fluid , aché , cholinergic , dementia , medicine , cholinergic neuron , alzheimer's disease , endocrinology , senile dementia , degenerative disease , disease , chemistry , enzyme , biochemistry
We have studied, as a possible marker of cholinergic neurons, the acetylcholinesterase (AChE) activity in cerebrospinal fluid (CSF) of 21 SDA patients and 9 controls of similar age with no neurological disease. The AChE activities were significantly lower in the SDA patients compared to the controls. The AChE activities were also lower in the most severely demented patients compared to those who were less severely demented but the difference was not statistically significant. As a potential glia marker, β‐glucuronidase activity in CSF was studied, but no significant difference was found in the activities of the SDA patients compared to the controls. The reduced AChE activities in the CSF of the SDA patients may be related to the loss of cholinergic neurons or disturbed cholinergic metabolism in the brain.