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Cerebrospinal fluid investigations in multi‐infarct dementia and senile dementia
Author(s) -
Wikkelsø C.,
Blomstrand C.,
Nordquist P.
Publication year - 1981
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1981.tb04380.x
Subject(s) - lactate dehydrogenase , albumin , uric acid , dementia , cerebrospinal fluid , medicine , endocrinology , antibody , pathology , chemistry , gastroenterology , enzyme , immunology , biochemistry , disease
Thirty‐eight demented patients were clinically investigated and classified into a multi‐infarct dementia (MID) and senile dementia (SD) group. Total protein, albumin, immunoglobulin G, agar gel electrophoretic protein and iso‐electric focusing pattern were determined in CSF and serum as well as the lactate dehydrogenase, LD‐iso‐enzyme pattern and uric acid. No significant differences were found regarding total protein, albumin and immunoglobulin G. The agar gel electrophoresis showed a tau‐globulin increase in 18% of the SD‐group against 6% of the MID group. The patterns were, however, plasma‐like in 56% of the MID group against 23% of the SD group. The iso‐electric focusing pattern showed an abnormal band in some SD‐patients which was not found in the MID group. The uric acid and LD‐enzyme concentration was equal in both CSF and serum. An index was calculated to give an approximate correction for the influence of different permeability of the blood‐brain and CSF barrier. A significantly higher LD‐index was found in the SD‐group, suggesting a continuous cell degeneration.