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Reactivity of the cerebrovascular bed to carbon dioxide in patients with primary high haematocrit before and after venesection
Author(s) -
Wade J. P. H.
Publication year - 1981
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1981.tb00784.x
Subject(s) - reactivity (psychology) , carbon dioxide , cerebral blood flow , blood flow , medicine , hematocrit , anesthesia , cardiology , chemistry , pathology , alternative medicine , organic chemistry
Paired cerebral blood flow measurements at 2 levels of arterial carbon dioxide tension ( PaCO 2 ) were made in 10 subjects with an elevated haematocrit and blood viscosity. A value of 32 was obtained for the percentage change in flow per kPa change in PaCO 2 ( CO 2 reactivity). The haematocrit was then lowered by venesection from 0.536 to 0.458 and the measurements were repeated. The post‐venesection CO 2 reactivity was 29, which was not significantly different from the pre‐venesection value. Thus CO 2 reactivity is not comprised in patients with low cerebral blood flow secondary to an elevated haematocrit.