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Effects of withdrawal from long‐term diphenylhydantoin treatment on audiogenic and maximal electroshock‐induced seizures in rats
Author(s) -
Lima Thereza C. M.,
Neto João Palermo
Publication year - 1981
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1981.tb00771.x
Subject(s) - convulsant , anesthesia , convulsion , medicine , epilepsy , pharmacology , psychology , neuroscience , receptor
Rats withdrawal from long‐term diphenylhydantoin treatment (DPH) were tested for their sensibility to convulsant stimuli. Animals were more sensitive to convulsions elicited by maximal electroshock and sound, respectively, at 48 and 72 h after drug removal. These results suggest that long‐term DPH treatment might develop a central nervous system supersensitivity state.