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The cerebrospinal fluid C 4 complement component in different meningeal and neurological diseases
Author(s) -
Mavrikakis M.,
Papageorgiou C.,
Kondou I.,
Chondrokoukis N.,
Pavlatou M.
Publication year - 1980
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1980.tb03036.x
Subject(s) - cerebrospinal fluid , medicine , pathology , complement (music) , meninges , complement system , central nervous system , meningitis , immunology , biology , antibody , surgery , biochemistry , complementation , gene , phenotype
The C 4 complement component was measured in CSF from 10 patients without CNS involvement (controls) and 71 with various meningeal and neurological diseases. Serum C 4 was also measured in the control group and in 46 of the 71 neurological patients. A significant increase of CSF C 4 was observed in all neurological diseases with meningeal involvement independent of the causative agent. Inversely, serum C 4 values were within normal limits. Increased CSF C 4 with normal serum levels might indicate increased diffusion across the blood‐brain barrier, decreased ability for immuno‐complex production or increased local production.