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Anti‐depressive treatment in Parkinson's disease A CONTROLLED TRIAL OF THE EFFECT OF NORTRIPTYLINE IN PATIENTS WITH PARKINSON'S DISEASE TREATED WITH L‐DOPA
Author(s) -
Andersen J.,
Aabro E.,
Gulmann N.,
Hjelmsted A.,
Pedersen H. E.
Publication year - 1980
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1980.tb03028.x
Subject(s) - nortriptyline , parkinsonism , parkinson's disease , placebo , depression (economics) , depressive symptoms , disease , medicine , clinical trial , rating scale , psychology , psychiatry , amitriptyline , anxiety , pathology , alternative medicine , developmental psychology , economics , macroeconomics
Nineteen patients with L‐DOPA treated parkinsonism involving depressive symptoms, the therapeutic effect of nortriptyline was compared to placebo in a controlled trial. The depressive and neurological symptoms were evaluated by rating scales. Nortriptyline had a clinical significant effect with regard to the depressive symptoms, whereas the neurological parameters were unchanged. The authors suggest the depression in Parkinson's disease to be of both reactive and endogenous origins.