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The blood‐brain barrier in adrenaline‐induced hypertension
Author(s) -
Johansson Barbro B.,
Martinsson Lena
Publication year - 1980
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1980.tb03009.x
Subject(s) - alertness , propranolol , evans blue , medicine , blood–brain barrier , endocrinology , metoprolol , albumin , anesthesia , central nervous system , pharmacology
Rats were subjected to adrenaline‐induced acute hypertension during either the day or the night. Albumin leakage into the brain was studied with Evans blue and 125 I labeled serum albumin. The leakage was significantly lower during the night than during the day ( P < 0.001). d,1‐propranolol had a protective effect ( P < 0.001) during the day and a slight reduction of the radioactivity ( P < 0.05 in some parts of the brain) was obtained by metoprolol (10 mg/kg) but not by butoxamine (10 mg/kg). None of the drugs reduced the tracer leakage during the night. The results suggest that the degree of alertness is of importance for the function of the blood‐brain barrier in acute hypertension. However, the present experimental situation does not allow a separation of the effect of alertness per se and dark/light cycles. The changed vulnerability during the night could be related to enhanced neuronal activity, altered beta‐adrenoreceptor sensitivity or to hormonal factors.