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Cimetidine in the prophylaxis of migraine
Author(s) -
Nanda R. N.,
Arthur G. P.,
Johnson R. H.,
Lambie D. G.
Publication year - 1980
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1980.tb03008.x
Subject(s) - cimetidine , migraine , medicine , placebo , histamine , anesthesia , crossover study , double blind , alternative medicine , pathology
The prophylactic effect of the histamine H 2 ‐blocker cimetidine, either alone or combined with an H 1 ‐blocker (chlorpheniramine), was investigated in 34 migraine patients in a double‐blind crossover trial. Twelve patients withdrew during the course of the trial, one because of side effects and the remainder because of failure to attend checkups or to keep adequate record of attacks. In the 22 patients who completed the trial, there were no significant responses to cimetidine or cimetidine + chlorpheniramine, during 3 months’therapy, as compared with 3 months’therapy with placebo, either on number, duration or severity of attacks. The study demonstrates that cimetidine is unlikely to be effective in migraine, and casts doubt on the role of histamine in the development of migraine attacks.