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Oligoclonal gamma‐globulin of cerebrospinal fluid in neurobrucellosis
Author(s) -
Silva Carlos Alberto,
Rio Maria Edite,
MaiaGonçalves António,
Pereira Síalvia,
Palmeira Manuela,
Brito Maria Regina,
Cruz Celso
Publication year - 1980
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1980.tb02994.x
Subject(s) - cerebrospinal fluid , gamma globulin , albumin , csf albumin , globulin , medicine , pathology , immunology , cerebrospinal fluid proteins , antibody
The clinical manifestations and laboratory findings of two cases of neurobrucellosis are described. The cerebrospinal fluid (CSF) protein electro‐phoresis showed increased gamma‐globulins and decreased relative values of pre‐albumin and albumin, associated to high values of total CSF protein. The evidence of oligoclonal morphology of CSF gamma‐globulins suggests that part of them had an intrathecal origin, in addition to an increased crossing of the damaged blood‐CSF barrier. Similar oligoclonal appearance of CSF gamma‐globulins was observed in two additional cases of neurobrucellosis previously reported.