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Hereditary spastic paraplegia with neurogenic bladder disturbances and syndactylia
Author(s) -
Opjordsmoen Stein,
NybergHansen Rolf
Publication year - 1980
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1980.tb02993.x
Subject(s) - hereditary spastic paraplegia , paraplegia , paresis , spastic , medicine , neurological disorder , central nervous system disease , surgery , physical medicine and rehabilitation , spinal cord , biology , phenotype , cerebral palsy , psychiatry , genetics , gene
The present paper reports a family settled in the northern part of Norway, with a hereditary neurological disorder consisting clinically of spastic paraplegia associated with neurogenic bladder disturbances and syndactylia. Nine out of 22 members in three generations exhibit these clinical features. The bladder disturbances, being incomplete supranuclear bladder paresis (uninhibited neurogenic bladder), were the main complaint and occurred at an early stage of the disease. The family probably represents an unusual form of hereditary spastic paraplegia (HSP). The mode of inheritance is considered to be autosomal dominant.