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Low somatostatin content in cerebrospinal fluid in multiple sclerosis
Author(s) -
Sørensen Kurt Virring,
Christensen Stig Engkjær,
Dupont Erik,
Hansen Aage Prange,
Pedersen Ejner,
ØRskov Hans
Publication year - 1980
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1980.tb01481.x
Subject(s) - somatostatin , cerebrospinal fluid , multiple sclerosis , medicine , endocrinology , radioimmunoassay , gastroenterology , chemistry , immunology
In 27 patients with multiple sclerosis (MS), and in 10 control subjects of comparable age, percent ideal body weight and sex ratio, the cerebrospinal fluid (CSF) content of somatostatin was measured by radioimmunoassay. The results showed that the group of patients in relapse (n = 16) had significantly lower somatostatin content in CSF (95 ± 4.1 (SEM) pg/ml) than both the control group (142 ± 8.4 pg/ml) and the group of MS patients (n =11), who had been in a clinical stable phase for more than 6 months (131 ± 3.2 pg/ml). Duration of the disease and degree of neurological impairment were apparently without relation to the reduction of somatostatin content in the CSF. There was no relationship between CSF content of somatostatin and the content of total protein or IgG, neither of which showed any relationship to the activity of the disease.