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Neonatal 6‐hydroxydopamine treatment increases the vulnerability of the blood‐brain barrier to acute hypertension in conscious rats
Author(s) -
Johansson Barbro B.
Publication year - 1979
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1979.tb02970.x
Subject(s) - extravasation , medicine , hydroxydopamine , blood pressure , bicuculline , blood–brain barrier , anesthesia , endocrinology , cerebral blood flow , central nervous system , dopamine , pathology , receptor , dopaminergic , gabaa receptor
Acute hypertension increases the cerebrovascular permeability to protein to a higher extent in anesthetized than in conscious rats. When hypertension is combined with a pronounced cerebral vasodilatation, e.g. in bicuculline‐induced seizures, the protein leakage is enhanced. Conscious, unrestrained 2‐3‐months‐old rats received adrenaline or bicuculline i.v. during continuous recording of the mean arterial pressure and were killed 3 minutes later. Rats, neonatally sympathectomized by 6‐hydroxydopamine, had significantly increased extravasation of 125 I serum albumin in the brain after adrenaline‐induced hypertension than nonsympathectomized rats. Since transection of the cervical sympathetic trunk alone does not have the same effect, a protection of the blood‐brain barrier in acute hypertension in conscious rats may, at least in part, be mediated via the central noradrenergic innervation of cerebral vessels. Bicuculline did not increase blood pressure in 6‐OHDA treated rats; thus the blood‐brain barrier remained intact.