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Blood‐brain barrier to albumin in awake rats in acute hypertension induced by adrenaline, noradrenaline or angiotensin
Author(s) -
Johansson Barbro B.,
Martinsson Lena
Publication year - 1979
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1979.tb02969.x
Subject(s) - medicine , angiotensin ii , endocrinology , blood pressure , albumin , jugular vein , renin–angiotensin system , adrenergic , blood–brain barrier , epinephrine , anesthesia , central nervous system , receptor
Acute hypertension was induced by adrenaline, noradrenaline or angiotensin in awake unrestrained rats with chronic indwelling catheters in a jugular vein and in the aorta. The leakage of 125 IHSA (human serum albumin) into the brains from rats given adrenaline was significanlty larger than in the brains from rats given noradrenaline or angiotensin. It is likely that the enhanced vulnerability of the blood‐brain barrier to an adrenaline‐induced increase in blood pressure is due to the beta‐adrenergic stimulating effect of adrenaline.