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DDAVP, a synthetic analogue of vasopressin, in prevention of headache after lumbar puncture and lumbar pneumoencephalography
Author(s) -
Hansen P. E.,
Hansen J. H.
Publication year - 1979
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1979.tb02967.x
Subject(s) - medicine , vasopressin , lumbar puncture , lumbar , pneumoencephalography , anesthesia , placebo , incidence (geometry) , nasal administration , cerebrospinal fluid , surgery , pharmacology , physics , alternative medicine , pathology , optics , radiology
In a double‐blind controlled trial the possible prophylactic effect of intranasally applicated DDAVP (1‐desamino‐8‐arginine vasopressin, Minurin®) ‐ a synthetic analogue of vasopressin ‐ is evaluated regarding the incidence of headache following lumbar puncture (LBP) in 51 patients and following pneumoencephalography (PEG) in 28 patients. DDAVP had no statistically significant effect on the incidence of headache or on the consumption of analgesics in the DDAVP‐versus placebo groups (minimal relevant difference = 50 %, 2é= 0.05, β= 0.50).