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Side effects of sodium valproate during long‐term treatment in epilepsy
Author(s) -
Ruuskanen I.,
Kilpeläinen H. O.,
Riekkinen P. J.
Publication year - 1979
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1979.tb02959.x
Subject(s) - side effect (computer science) , epilepsy , medicine , sodium , hair loss , gastroenterology , valproic acid , anesthesia , dermatology , chemistry , psychiatry , organic chemistry , computer science , programming language
Side effects of sodium valproate during long‐term treatment have been evaluated retrospectively in 55 patients suffering from refactory epilepsy. The side effects discovered in the study were slight and transient. In three of the 55 patients CNS side effects were noticed. Gastrointestinal symptoms were uncommon. One patient suffered from loss of hair which could have been attributed to sodium valproate. Severe side effects such as abnormal blood counts or organ damage were not discovered. The frequency of side effects was similar to those already reported in the literature except for gastrointestinal symptoms which were more infrequent than previously reported. No direct correlation could be established between the serum concentration of sodium valproate and the side effects.