Premium
Cerebral blood flow, cerebrovascular resistance and cerebral metabolic rate of oxygen in severe arterial hypoxia in dogs
Author(s) -
EkströmJodal Barbro,
Elfverson Jörgen,
Von Essen Claes
Publication year - 1979
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1979.tb02948.x
Subject(s) - hypercapnia , cerebral blood flow , hypoxia (environmental) , cerebral perfusion pressure , anesthesia , vasodilation , medicine , blood pressure , cerebral hypoxia , oxygen tension , oxygen , hypoxic hypoxia , cardiology , vascular resistance , arterial blood , cerebral circulation , ischemia , chemistry , acidosis , organic chemistry
Cerebral blood flow and cerebral oxygen uptake were studied during severe arterial hypoxia in anesthetized dogs. It was shown that the hypoxic vasodilatation in the brain reaches a limit at an arterial oxygen saturation at about 25 % and that this vasodilatation is less than that which may be induced by hypercapnia. A further deepening of the arterial hypoxia at a maintained cerebral perfusion pressure is combined with a continuous decrease in cerebral venous oxygen tension and a reduced oxygen uptake.