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Genetic basis of multiple sclerosis: HLA antigens, disease progression, and oligoclonal IgG in CSF
Author(s) -
Stendahlbrodin L.,
Link H.,
Möller E.,
Norrby E.
Publication year - 1979
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1979.tb02940.x
Subject(s) - multiple sclerosis , immunology , human leukocyte antigen , measles virus , medicine , antigen , titer , antibody , measles , vaccination
The HLA antigens B7 and Dw2 occurred at elevated frequencies in 105 multiple sclerosis (MS) patients (49 and 47%, respectively), compared to healthy controls (29 and 30%), especially in MS patients with oligoclonal CSF‐IgG (51 and 50%), in cases with CSF‐IgG index values above 1.5 (64 and 64%), and in those with the most malignant course of the disease (47 and 59%). Normal or only slightly elevated frequencies of B7 and Dw2 were found in MS patients without oligoclonal CSF IgG (35 and 29%), normal CSF‐IgG index (43 and 39%), and the most benign course (42 and 37%). No correlation was found between the HLA type and measles virus antibody titers in serum or a measles virus antibody response within the CNS.